Biomarkers and Progression of Cardiovascular-Kidney-Metabolic Syndrome: A Systematic Review and Meta-Analysis

The Cardiovascular-Kidney-Metabolic (CKM) syndrome, formally proposed by the American Heart Association in 2023, underscores the interdependent relationships among cardiovascular dysfunction, chronic kidney disease, and metabolic risk factors. While biomarkers are pivotal for early detection, risk stratification, and prognosis in CKM, a comprehensive synthesis of evidence linking diverse biomarkers to its multifaceted clinical outcomes is currently…

Leveraging Explainable Machine Learning to Predict Diabetes Remission After Bariatric Surgery

Bariatric surgery has become a powerful therapy for patients with obesity and type 2 diabetes mellitus (T2DM) whereby significant weight decreases are achieved, and metabolic remission can take place. However, remission rates differ widely, making predictive tools that support personalized care crucial.The intent of the present study was to generate and test machine learning (ML)…

Gum hypertrophy and Amlodipine

Amlodipine is one of the dihydropyridine commonly used to treat hypertension. We present case of a young woman who  noticed gum hypertrophy 2 months after starting the amlodipineObservation made. Pt was seen by Dentist and agreed the amlodipine most likely culprit Prior to medication use , she had regular check up with dentist and her…

Review the data, guides and programs of Acute Rheumatic Fever in New Zealand and the role of rural General Practitioners.

According to Health XXX surveillance data, the incidence of first-episode acute rheumatic fever (ARF) hospitalisations among Māori has declined by approximately 35% when comparing 2007/2008 with 2024/2025.Guided by Te Tiriti o Waitangi and an explicit equity-focused approach, a comprehensive framework of prevention and care initiatives has been implemented. This includes regular updates to national clinical…

The Göktaş Definition of Family Medicine/General Practice: A Global Health Project for Acting for more Liberty, Equity and Fraternity

There are some differences between countries in the practice of family medicine, which is the basis of countries' health systems and has a complex structure. These different characteristics make it difficult to develop family medicine standards globally. Family medicine practice is a medical discipline and has core values. Today, different practices of family medicine among…

Socioeconomic vulnerability and prenatal care provision in São Paulo State, Brazil: a spatiotemporal analysis

Adequate prenatal care is a cornerstone of primary health care and a key determinant of maternal and neonatal outcomes. In Brazil, prenatal care is delivered within primary care, making territorial analyses relevant. The ratio of prenatal consultations to live births (PNC/LB) serves as a proxy for service provision intensity, accessibility, and equity when analyzed alongside…

The effect of bilateral non-ivasive vagus nerve stimulation on stress in healthy adults

Stimulation of the vagus nerve influences biomarkers associated with both the hypothalamic–pituitary–adrenal (HPA) axis and the autonomic nervous system.The goal of the study was to evaluate the effect of transcutaneous vagus nerve stimulation (tVNS) on stress biomarkers and related symptoms and compare the effect of unilateral and bilateral stimulation.Total of 37 participants remained throughout the…

Family Physicians’ Perspectives on Artificial Intelligence in Kosovo’s Primary Healthcare: Opportunities, Challenges, and Ethical Reflections

Artificial Intelligence (AI) is increasingly recognized as a transformative force in healthcare, offering opportunities to enhance diagnostic accuracy, streamline administrative processes, and improve patient outcomes. In resource-constrained settings like Kosovo, the integration of AI into primary care could address systemic challenges such as workforce shortages, fragmented health data systems, and the growing burden of chronic…