Given the whopping number of drugs on the market, finding a unique brand name has become a major challenge for manufacturers. Therefore, naming agencies must imagine novel strategies that do not contravene health authorities' stringent regulations.The main objectives of our study were to (1) review the most widely used naming strategies and (2) identify the novel ones, based on a corpus of all 220 drugs that were approved by the FDA between 2021 and 2025.We conducted a mixed analysis. The primary outcome was the lexicological matrices. We first examined how the names were formed from a linguistic point of view. We investigated whether some letters and sounds were more popular than others. We checked whether the names or part of the names had a meaning in English, and whether they conveyed an imagery or a value. Eventually, we extracted and analysed those that were particularly interesting from a linguistic and a semantic point of view.80% of the names contained three or more syllables. 40% contained the letter Y. 9% exhibited double letters. 4% included a silent H. 12% started with O. 4% had an unconventional structure. 15,5% contained the [vi] sound. From a semantic point of view, 80% of the names were motivated either because they embedded part of the name of the drug's molecule or included a reference to the drug’s medical indication. 14% embedded part of a real word that had a meaning in English.Most names have three syllables to be distinctive. Distinctiveness is also enhanced using downstroke letters like Y, and including a silent H. Several names embed meaningful words that convey positive values. Developing brand names that include double letters and use imageries to address specific consumers (e.g., African-Americans) are among the most novel naming strategies.The FDA recommends that the brand name be neutral not to influence consumers and prescribers. But the prescription drug market is highly competitive. Therefore, developing a unique name is paramount for pharmaceutical companies. As for the future, naming agencies will need to discover unusual sequences of letters, borrow images from new fields and rely on AI.