In Brazil, the expansion of higher education in recent decades has occurred within a context of significant privatization, particularly in medical programs, which have historically been accessed mainly by students from privileged social backgrounds. Integrating medical students into the Unified Health System (SUS) promotes training aligned with humanization and comprehensive care, fostering closer connections between medical practice and community needs. Violence driven by gender inequality, racism, xenophobia, and other forms of intolerance has profound health impacts and reveals important gaps in medical education, especially regarding the preparation of future physicians to address situations of social vulnerability.To describe reported cases of violence motivated by gender, racism, xenophobia, and other minority-related issues in the city of São Paulo in 2022, and to discuss their implications for undergraduate medical education.This cross-sectional, descriptive, and retrospective study analyzed data from the Information System for Violence and Accident Surveillance (SIVVA) of the São Paulo Municipal Health Department. A total of 11,643 reported cases of violence involving city residents were included. Cases were categorized according to the motivation for violence, victim life stage and sex, characteristics of the violent act, relationship to the perpetrator, and perpetrator sex.Among reported motivations, sexism accounted for 51% of cases, followed by homophobia/lesbophobia/transphobia (3.3%), racism (0.7%), and xenophobia (0.3%). Most victims were adults (59.2%), followed by adolescents (22%) and children (11.9%). Violence was predominantly perpetrated by third parties (88.9%), with male aggressors responsible for most cases (75.2%). Recurrent episodes of violence were identified in 44.5% of reports.The findings highlight the need for medical education to incorporate a critical approach to social determinants of health, cultural diversity, and vulnerability. Exposure to real-world contexts of violence, particularly within primary health care settings, supports the development of reflective and socially responsive physicians capable of addressing complex care demands beyond a strictly biomedical perspective.The analysis of violence motivated by gender, racism, and xenophobia reinforces the importance of integrating discussions on social inequalities and vulnerability into medical training. This approach promotes cultural competence, humanized care, and greater preparedness to manage violence-related situations in clinical practice.