Breast cancer is the most common malignancy among women worldwide and a leading cause of cancer-related death. Early detection in primary care improves outcomes, highlighting the key role of frontline providers in screening.The aim of our study was to emphasize the pivotal role of primary care in breast cancer screening and to assess its impact on the early detection of breast malignancies.We conducted a prospective interventional study involving 2,302 patients who presented to our institution over a three-year period, from October 2022 to October 2025. All patients who underwent breast imaging during this timeframe were included in the study.The average age of participants was 50 years (range 20–86), with a strong female predominance (9 males). Routine screening accounted for 65.7% of visits, while 34.3% presented with breast symptoms. All patients underwent clinical breast examination and structured interviews. Breast imaging (mammography ± ultrasound) was performed in 2,039 patients, including 1,632 with combined assessment. ACR classification showed mainly benign findings: 34.82% ACR1 and 39.64% ACR2. Probably benign lesions (ACR3) represented 19.05%, while suspicious lesions (ACR4 and ACR5) accounted for 5.47% and 0.68%, respectively. All male patients had bilateral gynecomastia. Core needle biopsy was indicated in 215 patients. Histopathology from 61 patients revealed invasive ductal carcinomas, 119 benign lesions, which were subsequently reassured.Our findings reinforce the strategic role of primary care in providing accessible breast cancer screening and enabling timely detection. However, experience from a regional investigation shows that limited patient awareness remains a major obstacle to adherence, highlighting the need for targeted educational initiatives. In our study, mammography proved effective in identifying suspicious lesions early, consistent with international evidence demonstrating up to a 63% reduction in mortality in settings with well-organized, high-quality screening programs. Global analyses from 2015 to 2021 also show greater declines in mortality in countries with regular, structured screening.Primary care is pivotal to breast cancer screening owing to its accessibility and its crucial role in promoting awareness. Improved access to imaging is still needed to enhance early detection. Strengthening primary care involvement is therefore essential to optimizing screening efforts and reducing breast cancer mortality.