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Severe Falciparum Malaria in a Returning Traveler: A Primary Care Reminder of Travel History and Red Flags

Cinthya HERNÁNDEZ, Claudia JIMÉNEZ HERNÁNDEZ and Isabel GARCÍA CHUECO

Malaria is rarely encountered in Taiwan, making early recognition challenging for primary care physicians. Travelers returning from endemic regions without prophylaxis remain at risk for severe Plasmodium falciparum infection. This case illustrates the importance of systematic travel history–taking and identification of red-flag symptoms in primary care.A 66-year-old healthy man presented to primary care with five days of anorexia, fever, gastrointestinal discomfort, dark urine, and malaise after returning from the Congo. He had not taken malaria prophylaxis. Examination revealed jaundice, icteric sclera, and lower limb edema. Laboratory testing showed thrombocytopenia, acute kidney injury, hepatic dysfunction, metabolic acidosis, and coagulopathy. A malaria smear confirmed P. falciparum parasitemia. As his condition deteriorated with oliguria and respiratory distress, he was promptly referred for intensive care, artesunate therapy, and continuous renal replacement therapy. Strengths: Early recognition of severity and timely referral. Limitations: Lack of initial point-of-care testing and incomplete pre-travel counseling opportunities.Severe falciparum malaria is rare in non-endemic regions like Taiwan, and few reports highlight its initial presentation in primary care settings. Unlike typical fever presentations, this case underscores multi-organ involvement occurring rapidly in a traveler without prophylaxis. The case adds to limited Asian literature on imported malaria requiring intensive care.This case reinforces the importance of routinely asking about travel history, recognizing red flags such as jaundice, dark urine, thrombocytopenia, and early organ dysfunction, and providing pre-travel malaria prophylaxis counseling. Primary care protocols could better integrate travel screening and risk stratification for febrile patients.Febrile returning travelers require a broad differential diagnosis. Severe malaria can mimic common viral or gastrointestinal illnesses but rapidly progresses to life-threatening complications. Early suspicion, diagnostic testing, and urgent referral are essential in primary care.This case highlights the critical role of family physicians in early recognition of severe malaria and the importance of preventive travel counseling. Timely referral and appropriate management can prevent mortality in imported malaria cases.