In the DIAMOND study (in Italy), the epidemiological data on AC derive from real-world studies conducted on large populations attending cardiology clinics. The red flags are very varied in the pathology and do not guide the diagnosisTo evaluate naive subjects for cardiac amyloidosis through red flags and laboratory and instrumental investigations15 General Practitioners participated in the study (Statte-Martina Franca 22,000 users), from the management archives we enrolled through a quarry (age ≥65 years, Heart failure, CKD, AF, Arrhythmia, Diarrhea, CTS, Persistent low back pain, Hypotension, azotemia, creatinine) 6369 patients who had clinical symptoms or instrumental data suspicious for AC. M: 2845 (44.7%); F: 3524 (55.3%), Age (mean ± STD): 76.9 ± 7.9.Symptoms suggestive of AC: Lp (12.4%); STC (8.4%); D (6.3%); SC (4.9%); AF (4.2%); A (3.2%). On 3781 patients with Urea and Creatinine, we calculated UCR and GFR with EPI-CKD and related them to AF. In a logistic regression [OR: 1.49 (1.15-1.86); p: 0.015]; Age [OR: 1.03 (1.01-1.05); p: 0.01]; Sex [OR: 0.99 (0.75-1.32); p: 0.79].Having a UCR ≥ 30 – ≤ 100 the risk of having AF is high, associated with GFR. Monitoring the UCR is crucial for the management of critically ill patients, as it provides information not only on cardio-renal function but also on water balance and protein metabolism.Having a UCR ≥ 30 – ≤ 100 the risk of having AF is high, associated with GFR. Monitoring the UCR is crucial for the management of critically ill patients, as it provides information not only on cardio-renal function but also on water balance and protein metabolism.