Some individuals infected with SARS-CoV-2 experience a wide range of mid- to long-term symptoms, a condition known as Long COVID. The long-term mental health consequences of the COVID-19 pandemic are of growing concern, particularly among individuals with Long COVID and cognitive complaints.To explore the presence and distribution of anxiety, depression, and stress in individuals with Long COVID with cognitive complaints in northern Barcelona (Spain).This cross-sectional study  included 155 diagnosed individuals with Long COVID who were recruited from the Aliança ProHEpiC-19 Cognitiu (APC) project. Sociodemographic characteristics were collected, and mental health outcomes were assessed using the self-administered Depression, Anxiety, and Stress Scale (DASS-21). Descriptive statistics, χ2 tests, and Poisson regression models were used for data analysis.High levels of psychological distress were observed in the sample, with a notable prevalence of severe stress and extremely severe anxiety. Symptoms of stress, anxiety, and depression were consistently high across sex categories, work settings, and educational levels. Significant differences were found in anxiety and depression according to age and job role, with individuals aged over 45 years and non-healthcare workers showing higher relative risks (p < 0.05).These findings indicate a substantial mental health burden among individuals with Long COVID and cognitive complaints. Elevated levels of anxiety, depression, and stress were observed across multiple groups, suggesting that psychological distress is a core component of Long COVID. Higher levels of distress were particularly evident among adults over 45 years of age and non-healthcare workers.This study highlights the significant psychological impact of Long COVID, underscoring the need for targeted mental health interventions. The integration of emotional and psychological support into clinical management plans for long COVID is strongly recommended. Further research is needed to better understand its complex mental health consequences and to inform effective, evidence-based care strategies.