Progressive Resistance Training (PRT) is an effective intervention against osteoporosis and sarcopenia in aging populations, however, long-term adherence is poor. A recent feasibility study by Lin et al. (2025) addressed this by implementing a physician-guided educational model, achieving a 54.5% success rate in referring participants to community-based training.This secondary analysis aimed to identify baseline physiological characteristics that might predict successful referral to long-term training and to quantify the physiological adaptations resulting from the short-term intervention.This is a secondary analysis of data from 11 subjects from the original trial. Non-parametric Mann-Whitney U tests were used for baseline comparisons, and the Wilcoxon signed-rank test for pre-post analysis. Key variables included bone mineral density (BMD) and Appendicular Lean Mass Index (ALMI) measured using whole-body dual-energy X-ray absorptiometry (DXA) scans, and fitness metrics including peak oxygen uptake (VO2), peak workload (W), and peak metabolic equivalents (METs) measured using cardiopulmonary exercise testing (CPET).Data from 11 female participants (median age 68) with diagnosed osteoporosis were analyzed; two also met criteria for sarcopenia. Participants were categorized as Successfully Referred (SR, n=6) or Unsuccessfully Referred (UR, n=5), however, only nine participants successfully completed the program. Baseline comparisons revealed no significant differences between SR and UR groups in osteoporosis severity (lumbar T-score, p = 0.647) and muscle mass (ALMI, p = 0.201). As expected for the brief program, no statistically significant post-intervention changes were observed in bone mineral density (lumbar T-score, p = 0.859) or muscle mass (ALMI, p = 0.575). Among the nine completers, the intervention elicited statistically significant increases in peak workload (27 W, p = 0.011) and peak oxygen uptake (VO2) (3.44 mL/kg/min, p = 0.027), irrespective of SR or UR groups.The lack of baseline physiological predictors suggests that adherence may be influenced more by psychosocial factors, such as a lower "perceived need" in fitter individuals, rather than physical capacity. Despite the short duration, the intervention successfully initiated meaningful cardiopulmonary improvements.A brief, physician-guided PRT program can substantially improve fitness in older women with osteoporosis. This approach offers a promising, feasible strategy for managing musculoskeletal health and facilitating transition to sustainable exercise.