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Persistent hoarseness as an initial presentation of laryngeal cancer: A case report

Zarina AYIK, Konul ABDULLAYEVA and Vildan MEVSIM

Laryngeal cancer is a common head and neck malignancy, strongly associated with tobacco use. Early symptoms may be subtle and are frequently first encountered in primary care. Persistent hoarseness lasting longer than three weeks—particularly in high-risk individuals—should prompt urgent evaluation. Family physicians play a critical role in recognizing red-flag symptoms and initiating timely referral.A 62-year-old man presented to a family medicine clinic with progressive hoarseness lasting one month. He also reported sore throat and unintentional weight loss of 7 kg over the same period. He was an active heavy smoker (approximately three packs per day) with a family history of lung cancer. He denied fever, night sweats, or dyspnea. Physical examination revealed marked dysphonia and a firm, non-tender left cervical lymph node measuring approximately 2 cm. Vital signs and basic measurements were within normal limits. Given the persistence of hoarseness, heavy tobacco exposure, weight loss, and cervical lymphadenopathy, a laryngeal malignancy was strongly suspected, and the patient was urgently referred to otorhinolaryngology. Three weeks later, the patient returned with hospital records. Fiberoptic and direct laryngoscopy revealed a suspicious laryngeal lesion, and biopsy confirmed squamous cell carcinoma of the larynx.This case illustrates how a common symptom such as hoarseness can represent an underlying malignancy and emphasizes the pivotal gatekeeping role of primary care in early cancer detection.Persistent hoarseness beyond three weeks should always be evaluated carefully in primary care. Smoking history, weight loss, and cervical lymphadenopathy are critical red flags. Family physicians should maintain a low threshold for urgent referral, as early recognition can significantly affect prognosis and treatment options.Laryngeal cancer often presents with voice changes before advanced symptoms develop. In busy clinical settings, hoarseness may be misattributed to benign causes. This case demonstrates how systematic assessment and awareness of risk factors in primary care can prevent diagnostic delay.Primary care physicians are essential in the early identification of laryngeal cancer. Careful history-taking, focused examination, and timely referral enable earlier diagnosis and improved patient outcomes. MeSH keywords (plain text): Laryngeal Neoplasms; Hoarseness; Primary Health Care; Smoking; Early Diagnosis; Squamous Cell Carcinoma