For people living with human immunodeficiency virus (PLWHIV), the advent of antiretroviral therapy has significantly improved both prognosis and quality of life. HIV infection is now considered a chronic disease. As patients age and comorbidities increase, the general practitioners (GPs)’s central role remains insufficiently described.To analyse the perceptions of GPs in the Hauts-de-France region in 2025 who have at least one PLWHIV among their patients, focusing on their views regarding the specificities and their position in their overall management of these patients.A quantitative, descriptive, cross-sectional study was conducted using on a questionnaire sent to GPs practising in the Hauts-de-France region who are registered as the primary care physician for at least one PLWHIV. Qualitative variables were compared using Chi-square or Fisher tests, quantitative ones with Student or Mann–Whitney tests (Shapiro–Wilk for normality); significance was set at p ≤ 0.05.Among the 773 practitioners contacted, 71 were included. GPs were most comfortable in vaccination (median 6/10 [IQR: 5-8]) and least comfortable in the management of iatrogenic risks (median 4/10 [IQR: 2-5]). Sixty-two percent routinely asked their patients about self-medication, and 95% checked for potential drug interactions when prescribing a new treatment. Nonetheless, vigilance regarding high-risk molecules (such as divalent cations and proton pump inhibitors) remained inadequate. Most GPs believed they played an essential role in overall care, particularly in reporting “affection de longue durée” (97%) and monitoring vaccinations (93%), with varying levels of compliance depending on the recommendations (75% reported pneumococcal vaccination, 29% hepatitis A vaccination). Some cancer screenings were well followed (e.g. no specific guidelines for prostate or breast cancer), while others, such as adaptation for anal margin screening were less applied (56%).GPs expressed a willingness to be involved in the follow-up of PLWHIV, despite moderate self-assessed confidence. Their practices are generally in line with recommendations, particularly regarding vaccinations, but attention to drug interactions and certain specific screenings remains suboptimal. Nearly half would like additional training. Strengthening coordination with specialists appears crucial.GPs lack confidence in managing PLWHIV but express a genuine desire to be involved in patient care.