Life expectancy has increased over the last century among older people, particularly those over 60 years. Aging is associated with increased disability, multiple chronic conditions and increased use of health services managed with polypharmacy. There are few studies on the knowledge and attitudes of patients regarding polypharmacy in XXX, hence it is unclear about the attitudes and what older people know about polypharmacy.The study aimed at obtaining an understanding  of older people’s knowledge, attitudes and beliefs about polypharmacy.A qualitative study using in-depth interviews of 15 patients aged 60 years and older taking more than five medications per day. The study was conducted at the Family Medicine Clinic of the XXX University Hospital in XXX. Data were analysed using NVivo 12 software.Most participants had a good understanding of their underlying health conditions but could not recall the specific names of the medications they were taking. Participants had diverse attitudes toward polypharmacy, with both positive and negative perceptions. Although adverse side effects were being reported, participants remained positive because they believed these medicines were beneficial. Religion, faith and living healthy lifestyles were perceived to contribute to their positive attitude toward polypharmacy. Stigma and the cost of medications were reported as barriers.This study carried out in a private tertiary care institution, provided valuable insights into the complexities of polypharmacy in older people. It highlighted the importance of patient education, fostering strong patient-provider relationships, de-stigmatization of medical conditions and the need for improving medication affordability and accessibility.Addressing the factors associated with polypharmacy can contribute to an effective and improved quality of life for older people managing polypharmacy. Further research could explore the knowledge, attitudes and beliefs regarding polypharmacy in older people attending public institutions in rural XXX