Research in primary care can be challenging, particularly when recruiting patients with acute illness. Regulatory, legal and logistical challenges, alongside fragmented funding mechanisms, add further complexity. These issues are even more pronounced in infectious disease research, where timely recruitment and coordination are critical. Established primary care research networks can provide the infrastructure, trusted relationships and operational readiness needed to roll out studies immediately when urgent questions arise, as seen during the COVID-19 pandemic. Without such networks, early evidence generation is delayed and opportunities to guide clinical practice and management are lost.- Increase awareness of existing initiatives such as GRIN (General Practice Research on Infections Network) and the 18-country primary care research network. – Share experiences from ongoing international studies and trials. – Explore common barriers to international collaboration in primary care infectious disease research. – Discuss opportunities to a unified approach to streamline future complex trials.Short presentations by network leaders followed by targeted discussion points to promote interactive dialogue. Participants will be invited to reflect on experiences, identify shared challenges and contribute ideas for strengthening international research capacity. SC will outline the history of international collaboration in infectious disease research. AvdV will present past and current trials focussing on respiratory infections across the 18-country network. AV will highlight audit opportunities within this network, also supporting antimicrobial stewardship, and demonstrate online options for wider participation. CB will present upcoming funding opportunities, including the Be-READY initiative.Participants will gain a clearer understanding of existing networks and opportunities to join. The workshop will facilitate sharing ideas, discuss practical solutions to operational barriers and encourage collaboration across countries to generate research ideas and support future trials.Strengthening international primary care research networks now will support faster, coordinated and more impactful evidence generation for infectious disease research and future pandemic preparedness.