Acute neuromuscular weakness in adolescents is uncommon but potentially life-threatening. Guillain-Barré syndrome (GBS), an immune-mediated neuropathy often following infection, requires early recognition and coordinated care. In primary care settings, family physicians are frequently the first point of contact, placing them in a critical position to identify red flags and initiate timely referral while addressing psychosocial impact.This practice-based case report describes a 17-year-old female who presented with rapidly progressive, symmetrical ascending weakness following a recent upper respiratory tract infection. Initial assessment in a family medicine outpatient clinic included a comprehensive neurologic examination, family assessment, and counseling. Key findings were flaccid paralysis, absent deep tendon reflexes, preserved sensation, and evolving functional dependence. The patient was promptly referred for inpatient care, where diagnostic work-up confirmed Guillain-Barré syndrome and intravenous immunoglobulin therapy was initiated. Ongoing management involved rehabilitation, adolescent medicine support, and structured family meetings. Functional recovery and caregiver burden were monitored longitudinally.While GBS is well described neurologically, this case emphasizes the family-centered role of the family physician in early detection, care coordination, counseling, and continuity beyond hospital discharge. Integrating clinical vigilance with family assessment tools and patient-centered counseling highlights an often underreported dimension of GBS management in adolescents.Early suspicion of GBS in primary care can significantly alter outcomes. Addressing emotional distress, family dynamics, and uncertainty alongside biomedical care reduced anxiety and improved engagement with rehabilitation. Family-centered counseling should be integrated early in acute neurologic illnesses.This case underscores the importance of recognizing ascending paralysis as a medical emergency and illustrates how family medicine bridges acute care, specialty referral, and long-term recovery. Adolescents face unique psychosocial vulnerabilities that warrant deliberate attention.Family physicians play a pivotal role in the early recognition and holistic management of Guillain-Barré syndrome. Timely referral, coordinated multidisciplinary care, and sustained family engagement can preserve function, dignity, and hope during recovery.   MeSH Keywords: Guillain-Barré Syndrome; Acute Flaccid Paralysis; Adolescent Health; Primary Health Care; Rehabilitation