Chronic pain is a major public health problem, affecting 20% of the French population. The General Practitioner (GP) is the linchpin of its management, but numerous studies suggest that this management is a source of difficulty and frustration for practitioners. A better understanding of these challenges is essential to improve training and the organization of primary care.The main objective of this study was to determine the difficulties encountered by general practitioners in the management of chronic pain. Secondary objectives were to analyze their practices and their emotional experience when facing these complex situations.This was a qualitative, exploratory, and multicentric study, conducted with certified and established general practitioners. The data collection method relied on semi-structured Peer Groups (GDP), allowing for a free and in-depth discussion of real clinical cases. The data were analyzed using an inductive thematic approach, with triangulation of analyses by the three authors to ensure the reliability of the results.The analysis identified and structured the difficulties into three main categories: 1.Patient-related difficulties: Complicated psychosocial context, subjectivity of pain, medical nomadism, unrealistic expectations. 2.Physician-related difficulties: Lack of initial and continuing training, feeling of powerlessness, fear of iatrogenesis. 3.Health system-related difficulties: Insufficient consultation time, difficulty accessing specialized structures (SDC), and lack of interprofessional coordination. The study also highlighted a strong emotional impact on GPs, notably a feeling of loneliness, powerlessness, and discouragement when facing these chronic situations.The results confirm and enrich the existing literature by proposing a clear categorization of the barriers to optimal management. They underline the necessity of a global and multidisciplinary approach, and highlight the urgent need for support and training for GPs. The main difficulty lies in managing the psychosocial context, uncertainty, and chronicity, which requires an adaptation of practices and a recognition of the complexity of the task.The management of chronic pain in general practice is a major challenge, a source of difficulty for practitioners. The results of this study call for concrete actions on training, the organization of primary care, and support for general practitioners, in order to guarantee a better quality of life for chronic pain patients.