Cutaneous leishmaniasis (CL) is a wide-reaching infection of major public health concern. In Tunisia, the disease is endemic in the south and the center of the country. However, new endemic areas are being reported.Cutaneous leishmaniasis (CL) is a wide-reaching infection of major public health concern. In Tunisia, the disease is endemic in the south and the center of the country. However, new endemic areas are being reported.This study aimed to describe the epidemio-clinical features of CL in the region of Mahdia.A retrospective study was conducted in the department of infectious diseases and internal medicine in the university hospital of Mahdia during 6 years (2017 – 2023) including all patients hospitalized for CL and presented an indication for systemic treatment. Diagnosis of CL was made clinically and confirmed by visualizing the amastigotes in microscopic examination of infected tissue.A total of 15 patients were enrolled in the study: 11 men and 4 women. The median age was 53.5 years old (36 – 73 years old). Diabetes mellitus was the most common comorbidity (33.3%). Lower and upper extremities were affected in 73.3% and 60% respectively. The median number of lesions was 5 (1 – 9 lesions). Ulcero-crusted cutaneous lesions were the most common form (80%). Systemic antimonials were the most common monotherapy regimen prescribed in 10 cases (66.6%). Metronidazole was prescribed in the other cases (33.3%). The outcome was favorable in all cases.In this series from a non-endemic region, CL mainly affected middle-aged patients, often with diabetes, and presented as multiple ulcero-crusted lesions. Systemic antimonials remain the first-line treatment for cutaneous leishmaniasis, while other drugs such as metronidazole also proved effective in our study. These findings highlight the need for clinicians working in non-endemic areas to remain vigilant for CL and to promptly seek microbiological confirmation in suspected cases.Even in non-endemic areas, the physicians should make the diagnosis of CL in front of a high clinical suspicion and then confirm it microbiologically.