CURRENT KNOWLEDGE ON THE MANAGEMENT OF ANKLE SPRAINS IN PRIMARY CARE: A SYSTEMATIC REVIEW OF THE LITERATUREObjective : Acute ankle sprains are one of the most common reasons for consulting a general practitioner. The aim of this study was to analyze recent data from the literature on the management of ankle sprains and compare it with previous French recommendations  and the new HAS 2025 recommendations.Materials and methods : This systematic review of the literature was conducted using the PubMed, Cochrane, Lissa, and Google Scholar databases, including randomized trials, meta-analyses, systematic reviews, and recommendations published between 2005 and 2024. The data were synthesized according to the main areas of management: diagnosis, initial treatment, immobilization, paraclinical examinations, drug treatments, rehabilitation, return to sport, alternative therapies, and surgery.Results : OARs are confirmed as the diagnostic tool of choice. The RICE protocol, although widely used, is based on a low level of evidence and provides only temporary symptomatic relief. Functional supports are superior to strict immobilization, except in rare cases of severe sprains. Paracetamol and topical NSAIDs are the first-line analgesics; oral NSAIDs should be reserved for selected cases, and opioids are not indicated. X-rays remain the first-line paraclinical examination, while ultrasound appears promising but requires further studies to clarify its role. Active, early, and proprioceptive rehabilitation is key to preventing recurrence, while passive modalities have not been shown to be effective. Return to sport must be individualized, guided by clinical, functional, and psychological criteria. Surgery does not provide lasting functional benefit and should remain exceptional.Discussion : The 2000/2004 recommendations were already ahead of their time, favoring functional treatment, paracetamol, and proprioceptive rehabilitation. Recent data confirm these choices and refine them, particularly through the use of topical NSAIDs, the relativization of the RICE protocol, and the use of validated scores (FAAM, Ankle-GO, ALR-RSI).Conclusion : Optimal management of ankle sprains is based on a functional approach that is well thought out and tailored to the clinical context. The 2025 recommendations confirm the relevance of historical guidelines, while incorporating recent evidence to guide follow-up and ensure a safe return to sport.