Civilian spaceflight is expanding, creating new clinical and legal responsibilities for general practitioners (GPs). Pre-flight medical clearance involves high-risk certification, disclosure duties, and potential liability if relevant conditions are missed. Post-flight symptoms may trigger insurance disputes over causation, non-disclosure, or operator responsibility. This workshop uses a staged clinical vignette to examine screening, diagnosis, documentation, and medico-legal accountability in recreational spaceflight.Participants will be able to: Describe legal and procedural requirements for medical clearance for spaceflight. Identify high-risk pre-existing conditions relevant to liability. Recognise common post-spaceflight clinical presentations. Analyse medico-legal dilemmas involving patient disclosure, operator duties, and clinician responsibility.Teaching methods A progressive-disclosure vignette guides small-group analysis. Each phase adds new clinical or legal information, prompting reinterpretation of risk and responsibility. Methods include case discussion, legal decision-tree mapping, insurer–patient–clinician roleplay, structured debate, and facilitated synthesis by three presenters (GP, legal expert, space-medicine specialist).   Workshop schedule (60 minutes) 0–5 min: Introduction 5–15 min: Phase 1 – Initial clinical presentation; differential diagnosis 15–25 min: Phase 2 – Spaceflight exposure; legal risk reframing 25–35 min: Phase 3 – Undisclosed pre-flight history; certification duties 35–50 min: Phase 4 – Insurance scenario; liability and causation exercise 50–58 min: Development of a “GP Spaceflight Legal Checklist” 58–60 min: Summary and Q&AParticipants will strengthen their ability to conduct legally sound fitness assessments, recognise post-spaceflight symptoms, and document encounters to withstand insurance and legal scrutiny. Skills are transferable to other emerging high-risk activities requiring specialised certification.As space tourism evolves, primary care clinicians must integrate medical judgement with legal accountability. Through a structured vignette, this workshop equips GPs to navigate certification, diagnosis, and medico-legal responsibility within this new aerospace-health landscape.