Hurler Syndrome is a rare lysosomal storage disorder with progressive multisystem involvement. Respiratory complications, particularly recurrent pneumonia, are a major cause of morbidity in affected children. These complications are often magnified in low socioeconomic settings where access to healthcare resources, preventive services, and continuity of care are limited. This family case highlights the interaction of biomedical illness, family dynamics, and social determinants of health in the care of a chronically ill child.This case involves JN, a 3-year-old Filipino female with recurrent pneumonia and probable Hurler Syndrome from a low socioeconomic nuclear family with adolescents and young children. A comprehensive family medicine approach was applied, integrating biomedical and developmental assessment with family-focused tools including Family APGAR, SCREEM, FICA Spirituality Tool, Health Belief Model, genogram, family lifeline, and ecomap. Counseling was conducted using the Catharsis–Education–Action (CEA) framework to address caregiver emotional distress, knowledge gaps, and coping strategies. Management combined pharmacologic treatment of pneumonia with non-pharmacologic interventions such as nutritional support, environmental modification, psychosocial counseling, health education, and coordination with government and community resources.This case uniquely integrates clinical management of recurrent pediatric pneumonia secondary to probable Hurler Syndrome with in-depth family systems and psychosocial assessment. It underscores the pivotal role of the family physician in coordinating care, mobilizing resources, and addressing caregiver mental health amid moderately inadequate family resources and major therapeutic efforts.Chronic pediatric conditions require holistic, family-centered care beyond disease-focused treatment. Early family assessment, caregiver mental health support, strong primary care involvement, and community resource mobilization are essential to improve resilience and outcomes in resource-limited settings.JN’s recurrent pneumonia is explained by Hurler Syndrome pathophysiology, including airway obstruction, impaired mucociliary clearance, cardiopulmonary compromise, immunologic vulnerability, and undernutrition. These risks are compounded by poor housing ventilation, shared sanitation, financial constraints, limited parental education, and social stigma. Family assessment revealed a moderately dysfunctional family with caregiver strain, mild maternal depression, and limited social and spiritual support. Targeted counseling, education, and resource linkage improved family engagement in care.Integrating biomedical management with family assessment and psychosocial support enables more sustainable and compassionate long-term care for children with Hurler Syndrome and recurrent pneumonia.