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Association between small vessel disease and persons with overweight and obesity: A study using peak width of skeletonized mean diffusivity

Jinseung KIM

Obesity and overweight are increasingly recognized as contributors to cerebrovascular disease, including cerebral small vessel disease (SVD). Peak width of skeletonized mean diffusivity (PSMD), derived from diffusion tensor imaging (DTI), provides a sensitive and automated marker of microstructural white matter (WM) damage associated with SVD. However, the relationship between body mass index (BMI) and PSMD in neurologically healthy individuals remains unclear.