Upper respiratory tract infections (URTIs) are among the most common reasons for primary care visits. Most URTIs are viral, yet antibiotics are frequently overprescribed, contributing to antimicrobial resistance. This case series highlights real-world prescribing patterns in general practice and emphasizes judicious antibiotic use.Six anonymized cases of URTI seen in general practice were collected. Data included patient age, symptoms, diagnosis (viral vs. bacterial), antibiotic prescription, and outcomeThis case provides real-world evidence of appropriate antibiotic prescribing for viral and bacterial URTIs in general practice, highlighting effective stewardship and contributing to the prevention of antimicrobial resistance.   This case series reinforces the importance of differentiating viral from bacterial URTIs in primary care to avoid unnecessary antibiotic use. This practice could improve prescribing practices and reduce antimicrobial resistance in broader clinical settings.This case series demonstrates that most URTIs in primary care are viral and do not require antibiotics. Appropriate prescribing reduces unnecessary antibiotic exposure and minimizes the risk of antimicrobial resistance. The cases highlight the importance of differentiating viral from bacterial infections and suggest that real-world audits of prescribing patterns can reinforce guideline-based practice and improve patient outcomes.”   Judicious antibiotic use in URTI management is essential. Case-based audits in general practice help reinforce guidelines, optimize patient care, and minimize the development of antimicrobial resistance.