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The Association between Hyperuricemia and Health-Related Quality of Life in Korean Adults: Based on the Seventh Korean National Health and Nutrition Examination Survey (2016-2017)

Monique AUBART

The prevalence of hyperuricemia have increased over the past few decades. Hyperuricemia is considered to be responsible for the increased risk of hypertension, type 2 diabetes mellitus, chronic renal disease, and cardiovascular disease. Health-related quality of life (HRQoL) is increasingly used as an outcome in clinical trials, effectiveness research, and research on quality of care.We aimed to analyze the association between hyperuricemia and HRQoL in Korean adults older than 19 years.We included 2,376 men and 2,593 women who participated in the Korea National Health and Nutrition Examination Survey from 2016 to 2017. Hyperuricemia was defined as serum uric acid 7mg/dL. The Euro quality of life-5 dimension (EQ-5D) instrument was used as the measure of HRQoL. A multiple logistic regression analysis was performed to examine the association between Hyperuricemia and HRQoL.The EQ-5D index score in hyperuricemia group was significantly lower than normal group. After adjusting for multiple covariates, the odds ratios (95% confidence intervals) for problems with mobility were 1.46 in men and 1.33 in women; however, the difference was not statistically significant for women.This study is meaningful in that hyperuricemia affects health-related quality of life not only in the elderly population but also in the young population in their 20s and 30s, suggesting that they need proper management of hyperuricemia.Hyperuricemia was associated with poor quality of life. It is important to control serum uric acid levels to improve HQoL.